The won by two strokes for his second PGA Championship title.
Sport24 takes a look at the golfers who will fly the SA flag:
Age - 37
Oosthuizen heads into the PGA Championship as the top-ranked South African golfer.
Oosthuizen has been paired in Round 1 with American Max Homa and Englishman Matthew Fitzpatrick, teeing off at 17:44 (SA time).
Age - 35
Best PGA Championship - T31 (2018)
The South African golfer, who now resides in Texas, is no stranger to winning in the US after securing his maiden PGA Tour victory last year at the John Deere Classic.
World ranking - 71
Norris received an invitation by the PGA of America to compete in San Francisco. The 38-year-old has made a name for himself on the Asian Tour and the Japan Golf Tour, where he has won a title for four consecutive years from 2016.
World ranking - 47
In his first seven PGA Tour events, Bezuidenhout has only missed the cut on two occasions, with a best finish of T18 at the Arnold Palmer Invitational.
Bezuidenhout will get his opening round under way alongside American duo Tyler Duncan and JR Roth at 21:30 SA time.